Adhesion receptor profile of thymic B-cell lymphoma.

摘要: Primary thymic B-cell lymphoma is clinically characterized by aleukemic, highly aggressive local growth, infrequent distant metastasis, and secondary lymph node involvement. VLA-1 to VLA-6 are cell surface molecules binding matrix such as collagen, fibronectin, epiligrin, laminin. VLA-4 additionally binds VCAM-1 ICAM-2, thus mediating intercellular adhesion. Other involved in cell/cell adhesion LFA-1 (CD11a/CD18), Mac-1(CD11b/CD18) their ligand ICAM-1 (CD54), p150,95 (CD11c/CD18), LFA-3 (CD58), CD44, LECAM-1. Twenty-three tumors, together with normal lymphoid tissue, were immunohistochemically examined investigate the expression pattern of these lymphomas putative counterparts, namely medullary B cells. Thymic consistently lacked VLA-1,-2,-3,-5,-6, CD11b, expressed 21 23 cases but heterogenous for VLA-4, LFA-1, CD11c, LFA-3, Presence correlated (P = 0.029). The receptor profile was reminiscent expressional status cells some aspects deviated others: Assuming that, terms differentiation, related asteroid variant cells, a propensity down-regulate/lose CD11a, LECAM-1 would have be supposed conjunction tendency overexpress LFA-3. Sclerosis an inconsistent phenomenon absent 8 tumors. sclerosis tumor 0.038). Recent studies suggest that locally growing/aleukemic phenotype neoplasia might determined VLAs-, LFA-1+, ICAM-1+, CD44-, LECAM-1-. Our data corroborate this view.