Canova, a Brazilian medical formulation, alters oxidative metabolism of mice macrophages

摘要: Summary Macrophages play a significant role in the host defence mechanism. When activated they can produce reactive oxygen species (ROS) as well related nitrogen (RNS). ROS are produced via NAD(P)H oxidase which catalyzes superoxide ( O 2 − ) formation. It is subsequently converted to hydrogen peroxide (H by either spontaneous or enzyme-mediated dismutation. Nitric oxide synthase (NOS) nitric (NO) Canova (CA) Brazilian medication with homeopathic techniques, composed of Aconitum , Thuya Bryonia Arsenicum Lachesis distilled water containing less than 1% ethanol. Previous studies demonstrated that CA neither toxic nor mutagenic and activates macrophages decreasing tumor necrosis factor-α (TNFα) production. In this assay we showed triggered increased activity iNOS, consequently producing NO respectively. Cytochrome peroxisomes activities were inhibited NO. As being at same time, formation peroxynitrite (ONOO may be occurring. A potential explanation provided on how treatment enhance immune functions could particularly important cytotoxic actions macrophages. considered new adjuvant therapeutic approach known therapies.