Method for identifying compounds or lead structures against rna target motifs and rna/protein interactions
作者： Andreas Jenne , Jörg Hartig , Michael Blind , Seyed Hani Najafi-Shoushtari , Michael Famulok
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摘要: Disclosed is a method for identifying compounds (lead structures) which specifically bind to (a) desired RNA target motif and can inhibit or eliminate the function thereof (b) suppress compound associated with thereby thereof. The inventive based on attachment of ligand (=a be identified) coupled modified ribozyme so that transformed into an active inactive conformation resulting in cleaving signal-giving substrate. identified enabling modification cellular motifs enable specific medicaments produced. invention also relates polynucleotide comprising hammerhead aptamer molecule. base pairing model polynucleotide, when molecule binds aptamer, different from does not aptamer.
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