Facile synthesis of 2-arylmethylindoles and 2-vinylic indoles through palladium-catalyzed heteroannulations of 2-(2-propynyl)aniline and 2-(2-propynyl)tosylanilide
作者： Bimolendu Das , Priyanka Kundu , Chinmay Chowdhury
DOI: 10.1039/C3OB41961D
关键词:
摘要: A facile method for the general synthesis of 2-arylmethylindoles has been developed through reaction 2-(2-propynyl)aniline or 2-(2-propynyl)tosylanilide with aryl iodides in presence Pd(OAc)2, PPh3, and DBU. 2-(2-Propynyl)tosylanilide is found to be reactive also towards electron deficient alkenes Pd(OAc)2 sodium iodide under an oxygen atmosphere, providing easy access 2-vinylic indoles which possess exclusive E-stereochemistry side chain double bond. Operational simplicity, compatibility various functional groups, ease product formation are hallmarks these methods. mechanism proposed explain formation.
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