Synthesis, structure, and complexing properties of macrocyclic receptors for anions

摘要: Understanding of structure-affinity relationships is crucial for rational receptor de- sign, however, such studies anion receptors are still limited. Therefore, we investigated this issue in the case amide-based macrocyclic derived from aromatic diacids (i.e., isophthalic and dipicolinic). Using these model compounds, examined macro- cyclic effect, influence intramolecular hydrogen bonds, correlation between ring size affinity. We found that contrast to what was known acyclic diamides, isophthalamide bind anions more weakly than their di- picolinic analogs. Comprehensive structural revealed behavior due bonds present receptors. Furthermore, demonstrated how obstacle can be overcome by preparation a hybrid macrocycle based on both building blocks.