Integrin expression profiles during erythroid differentiation.

摘要: To study the expression of integrins at erythroid progenitor level we isolated selected populations cells from human fetal liver after immunoadherence to anti-beta 2 integrin (CD18) coated plates. These CD18 adherent (CD18-Ad), in contrast nonadherent (CD18-NAd), have a blastlike cell morphology and are highly enriched all types (14% 37% progenitors). By several criteria present CD18-Ad appear higher proliferative potential diversity than ones found CD18-NAd, which were mostly later progenitors. Positivity with common beta is largely attributable alpha L (CD11a) chain, rather M (CD11b). CD11a progenitors, but it selectively lost stages differentiation/maturation. contrast, CD11b appears be virtually absent progenitors has an enhanced during granulomonocytic In addition integrins, express other cytoadhesion molecules (VLA-4, VLA-5, I-CAM, H-CAM) as well antigens (CD34, HLA-DR, CD38). Cells expressing these cells. Our data add new information on regulation hematopoiesis composite profile differentiation.