Effects of vasopressin and related peptides on neurons of the rat lateral septum and ventral hippocampus.

摘要: The effects of vasopressin (VP), VP fragments and propressophysin glycopeptide on neuronal activities in the septum-hippocampus complex rats were studied vitro vivo. frequency hippocampus theta rhythm Brattleboro homozygous for diabetes insipidus was significantly slower than that heterozygous litter mates normal rats. Intracerebroventricular micro-injection des-glycine-amide corrected several hours deficit centrally administered slowed down Microinotophoretically excited single neurons lateral septum ventral hippocampus, and/or facilitated responses these to glutamate stimulation glutamatergic afferent fibers fimbria bundle. excitatory vanished within seconds after termination peptide administration, however, peptide-induced enhancement syntatically induced excitations sustained up 60 min administration. In vitro, pM concentrations VP, 4-8 C-terminus propresophysin 30-60 glutamate-mediated EPSPs or hippocampus. increase not prevented by pretreatment with antagonist V1a type receptor. resting membrane potential input resistance affected peptides. A low-frequency electrical diagonal Band Broca Bed nucleus stria terminals, sources vasopressinergic innervation septum, negative wave filed potentials evoked stimulating bundle control Long-Evans insipidus. field stimulation, it occluded long-term potentiation elicited high fibers. failed show band stimulation. It is suggested long-lasting facilitation might be a physiological action propressophysin-derived peptides which, concert other forms synaptic plasticity like potentiation, facilitates hippocampus-mediated learning memory. This presumably related memory enhancing effect