Xylose catabolism in the experimental rat blind loop syndrome: Studies, including use of a newly developed d-[14C]xylose breath test

摘要: Abstract Intraluminal bacterial catabolism of xylose in an experimental rat blind loop model has been evaluated by means a newly developed d -[ 14 C]xylose breath test. The system employed affords frequent determination total CO 2 and the opportunity for post-therapy evaluation. Rats with jejunal self-filling loops expired 40% orogastric dose as over 6 hr, compared to 9% nonoperated control rats 17% surgical controls self-emptying loops. production decreased significantly neomycin treatment loops, was correlated significant decrease gram-negative coliforms contents. Small intestinal bacteria could be implicated up 76% rats, colon unabsorbed smaller additive factor.Intravenous administration demonstrated that cellular metabolism insignificant part output. Urinary excretion amount correlating intraluminal xylose. Thus, small intestine appears major determinant urinary syndrome, malabsorbed probable minor additional factor.