Polyethylene glycol derivatives, their modified peptides, methods for producing them and use of the modified peptides
作者： Yoshiharu Ikeda , Keiichi Ono , Yoshiyuki Kai
DOI:
关键词:
摘要: Polyethylene glycol derivatives of the formula ##STR1## wherein R 1 and 2 are same or different each represents a lower alkyl, m n positive integer p is 0 integer, peptides modified by polyethylene derivatives, methods for producing them use peptides. The (I) invention, as compared with corresponding non-modified peptides, show decreased antigenicity, considerably delayed in biological clearance, exhibit their physiological activities effectively over long period, rendering very effective pharmaceuticals well drugs animals.
glgoo.top参考文章(12)
Yuusaku Nishimura, Masahiko Ishida, Ryoichi Haga, Method for immobilization of enzyme and immobilized enzymes ,(1987)
Osamu Nishimura, Masahiko Fujino, Chemically modified lymphokine and production thereof ,(1985)
Yasushi Nakagawa, Takashi Ito, Chemically modified protein with polyethyleneglycol ,(1987)
Walter J. Laird, Lois Aldwin, Danute E. Nitecki, Paula J. Shadle, Margaret Moreland, John D. Young, Nandini Katre, Kirston E. Koths, Conjugation of polymer to colony stimulating factor-1 ,(1989)
Frank F. Davis, Theodorus Van Es, Nicholas C. Palczuk, Non-immunogenic polypeptides ,(1977)
Kouichi Miyata, Masahira Nakamura, Yasushi Nakagawa, Modified enzymes, production and use thereof ,(1986)
Makoto Morimoto, Masami Okabe, Motoo Yamasaki, Yoshiharu Yokoo, Modified human G-CSF ,(1989)
Ulrich Horlein, Horst Boshagen, Elisabeth Perzborn, Friedel Seuter, Gerd Reinhardt, Thrombin inhibitory new dihydroxybenzene ether derivatives ,(1982)
Akihiko Sano, Keiichi Ono, Hiroo Maeda, Yoshiyuki Kai, Polyethylene glycol derivatives, modified peptides and production thereof ,(1989)
Daiei Tunemoto, Kiyosi Kondo, Minoru Suda, Tamotsu Fujimoto, Process for preparing aromatic acetic acid ,(1979)