Sleep disturbances in men with asymptomatic human immunodeficiency (HIV) infection.

摘要: During the clinical latency phase of human immunodeficiency virus (HIV) disease central nervous system may be infected and begin to manifest subtle dysfunction. Our early investigations demonstrated persistent alterations in sleep architecture HIV-infected asymptomatic men. The major aims this study were delineate men, identify describe behavior complaints seek a correlation between objective parameters subjective behavior. sample consisted 24 14 10 HIV-negative, age-matched controls. protocol included comprehensive history physical, two polysomnograms, urine toxicity, detailed written questionnaire, Pittsburgh Sleep Quality Index, Spielberger State-Trait Anxiety Test Beck Depression Inventory. results indicated that differed from controls wakefulness, slow-wave [SWS-stage 3 4 nonrapid eye movement (NREM) sleep] stage rapid (REM) more evenly dispersed throughout night. In particular, SWS was prevalent during second half recorded sleep. observed changes NREM/REM cycle could not explained on basis underlying psychopathology. Just as course individuals with HIV infection varies, it is expected abnormalities will vary. Considering known relationships NREM immune function, possible are related coincident immunologic function. Quantitative measures sleep, especially REM perhaps greater significance than relative stages.(ABSTRACT TRUNCATED AT 250 WORDS)