Is Insulin Resistance a Feature of or a Primary Risk Factor for Cardiovascular Disease?
作者： Markku Laakso
DOI: 10.1007/S11892-015-0684-4
关键词:
摘要: The two major pathophysiological abnormalities in type 2 diabetes are insulin resistance and impaired secretion. Insulin is a general term meaning that does not exert its normal effects insulin-sensitive target tissues, such as skeletal muscle, adipose tissue, liver, the tissues for action glucose metabolism. (IR) promotes cardiovascular disease via multiple mechanisms, including changes classic risk factors downregulation of signaling pathways different tissues. This review presents evidence association with from clinical population-based studies. causality discussed on basis recent findings Mendelian randomization
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