Albuminuria after Renal Transplantation: Maintenance with Sirolimus/Low-Dose Tacrolimus vs. Mycophenolate Mofetil/High-Dose Tacrolimus

摘要: Maintenance immunosuppression with sirolimus (SRL) in renal transplantation has been associated proteinuria. We report long-term outcomes of kidney transplant recipients maintained on steroid-free regimens, either SRL low-dose tacrolimus (SRL/L-Tac) or mycophenolate mofetil (MMF) high-dose (MMF/H-Tac). conducted a case-matched study 50 patients receiving MMF/H-Tac, matched 1:2 100 SRL/L-Tac. All were induced rabbit antithymocyte globulin followed by early steroid withdrawal. Comparisons made patient and graft survival, function, acute rejection, albuminuria. There no significant differences between the SRL/L-Tac MMF/H-Tac groups for occurrence function. was difference proportion albumin/creatinine ratio (ACR) ≥300 μg/mg (19% vs. 20%), but more group renin-angiotensin system blocking agents (72% 53%, p = 0.04). Only flushing donor histidine-tryptophan-ketoglutarate solution (vs. UW solution) predictive Long-term are similar at our center MMF/H-Tac. Although albuminuria not different, significantly SRL-treated antiproteinuric medications.