1449-P: Longitudinal Changes in Sex Hormone Binding Globulin (SHBG) and Risk of Diabetes: The Study of Women's Health Across the Nation (SWAN)

摘要: Low circulating levels of sex hormone-binding globulin (SHBG), a putative marker androgenicity, have been associated with poor glucose control in studies conducted primarily among post-menopausal women. However, the relation long-term changes endogenous SHBG to risk type 2 diabetes (T2DM) women during and after menopause transition is unclear. We aimed assess longitudinal associations between developing T2DM such included 3,060 participants Study Women’s Health Across Nation (SWAN) who were free at baseline. SWAN cohort study up 17 years follow-up. measured 13 visits. Participants reported diagnosed status all visits, fasting was 8 follow-up defined based on self-report or levels. Women averaged 46 (SD=3) age 311 developed used complementary log-log-based discrete time survival models anchored baseline estimate incident T2DM. A 5-unit (nM) increase time-varying hazard ratio (HR) 0.86 (95% CI 0.82, 0.90), for T2DM, controlling race-ethnicity, age, cycle day blood draw, site, body mass index (BMI), testosterone, level. After adjusting covariates, lowest ((-92.0 - -1.1 nM/year) vs. highest quartile (0.7 42.1 time-invariant average rate change per year levels) had HR 5.18 CI: 3.55,7.56). No association observed other quartiles low and/or decreases increased develop Clinicians should be aware that declining mid-life strongly independent known factors. Disclosure M.M. Hedderson: None. C. Lee: A. Capra: J. P. Chang: E. Gold: Waetjen: L.A. Habel: S.R. El Khoudary: Funding National Institutes