Advances in lipid-based drug delivery: enhancing efficiency for hydrophobic drugs
作者： Gang Wang , JunJie Wang , Wei Wu , Shing Shun Tony To , HuaFu Zhao
DOI: 10.1517/17425247.2015.1021681
关键词:
摘要: Introduction: Many drug candidates with high therapeutic efficacy have low water solubility, which limits the administration and transport across physiological barriers, for example, tumor tissue barrier. Therefore, strategies are needed to permeabilize barriers safely so that hydrophobic drugs may be delivered efficiently.Areas covered: This review focuses on prospects application of lipid-based delivery carriers increase improve their bioavailability, release, targeting absorption. Moreover, novel techniques prepare extend pharmaceuticals poor bioavailability such as surface modifications presented. Industrial developments several employing these discussed, well applications clinical trials.Expert opinion: Overall, can encapsulated in systems, repre...
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