Non canonical genetic material.
作者： Elena Eremeeva , Piet Herdewijn
DOI: 10.1016/J.COPBIO.2018.12.001
关键词:
摘要: To increase the scope of natural biosystem, nucleic acids have been intensively modified. One direction includes development a synthetic alternative to native DNA and RNA, denoted Xenobiotic (XNAs) that are able store transfer genetic information either by base-modification or backbone-modification. Another line research aims develop third base pair additional A:T G:C. These unnatural pairs (UBPs) can increased content encoded in three pairs. This review outlines recent progress made towards XNA UBP applications as new components genomic well biostable aptamers. New achievements replacement bacterial genome non-canonical nucleotides also described.
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