RNA Interference and the Regulation of Renal Gene Expression in Hypoxia
作者： Carsten C. Scholz , Colin R. Lenihan , Cormac T. Taylor , Ulrike Bruning
DOI: 10.1007/978-1-60761-857-7_25
关键词:
摘要: Hypoxia is a common occurrence both in health and disease, it contributes to physiologic pathophysiologic processes through the regulation of gene expression. At cellular level, highly conserved signaling pathways that activate transcription factors, including (but not limited to) hypoxia-inducible factor (HIF) nuclear κB (NFκB) demonstrate hypoxic sensitivity modulate expression response changes microenvironmental oxygen concentrations. Recent evidence has revealed posttranscriptional mechanisms based on RNA interference are also critically important global In this chapter, we will discuss potential importance hypoxia with particular emphasis renal disease.
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