Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors.
作者： Chloe H. Lee , Mariolina Salio , Giorgio Napolitani , Graham Ogg , Alison Simmons
DOI: 10.3389/FIMMU.2020.565096
关键词:
摘要: Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR: pMHC interaction would have profound clinical, therapeutic and pharmaceutical applications. Herein, we review recent developments in predicting cross-reactivity and antigen specificity of TCR recognition. We discuss current experimental and computational approaches to investigate cross-reactivity and antigen-specificity of TCRs and …
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sci-hub.st 参考文章(224)
Marcus F.A. Mendes, Dinler A. Antunes, Maurício M. Rigo, Marialva Sinigaglia, Gustavo F. Vieira, Improved structural method for T-cell cross-reactivity prediction. Molecular Immunology. ,vol. 67, pp. 303- 310 ,(2015) , 10.1016/J.MOLIMM.2015.06.017
Henrique Veiga-Fernandes, Ulrich Walter, Christine Bourgeois, Angela McLean, Benedita Rocha, Response of naïve and memory CD8+ T cells to antigen stimulation in vivo. Nature Immunology. ,vol. 1, pp. 47- 53 ,(2000) , 10.1038/76907
Markus Cornberg, Shalyn C. Clute, Levi B. Watkin, Frances M. Saccoccio, Sung-Kwon Kim, Yuri N. Naumov, Michael A. Brehm, Nuray Aslan, Raymond M. Welsh, Liisa K. Selin, CD8 T Cell Cross-Reactivity Networks Mediate Heterologous Immunity in Human EBV and Murine Vaccinia Virus Infections The Journal of Immunology. ,vol. 184, pp. 2825- 2838 ,(2010) , 10.4049/JIMMUNOL.0902168
William E. Biddison, Kai W. Wucherpfennig, David N. Garboczi, Ursula Utz, Stefan Hausmann, Don C. Wiley, Kathrine J. Smith, Yuan-Hua Ding, Peptide Recognition by Two HLA-A2/Tax11–19-Specific T Cell Clones in Relationship to Their MHC/Peptide/TCR Crystal Structures Journal of Immunology. ,vol. 162, pp. 5389- 5397 ,(1999)
Mark Klinger, Francois Pepin, Jen Wilkins, Thomas Asbury, Tobias Wittkop, Jianbiao Zheng, Martin Moorhead, Malek Faham, Multiplex Identification of Antigen-Specific T Cell Receptors Using a Combination of Immune Assays and Immune Receptor Sequencing PLOS ONE. ,vol. 10, pp. e0141561- ,(2015) , 10.1371/JOURNAL.PONE.0141561
Stephen Smale, Hau-San Wong, Wen-Jun Shen, Quan-Wu Xiao, Xin Guo, Towards a Mathematical Foundation of Immunology and Amino Acid Chains arXiv: Machine Learning. ,(2012)
Johan Desmet, Ian A. Wilson, Marcel Joniau, Marc De Maeyer, Ignace Lasters, Computation of the binding of fully flexible peptides to proteins with flexible side chains. The FASEB Journal. ,vol. 11, pp. 164- 172 ,(1997) , 10.1096/FASEBJ.11.2.9039959
Karolina Malecek, Arsen Grigoryan, Shi Zhong, Wei Jun Gu, Laura A. Johnson, Steven A. Rosenberg, Timothy Cardozo, Michelle Krogsgaard, Specific Increase in Potency via Structure-Based Design of a TCR Journal of Immunology. ,vol. 193, pp. 2587- 2599 ,(2014) , 10.4049/JIMMUNOL.1302344
Andrew Leaver-Fay, Matthew J O'meara, Mike Tyka, Ron Jacak, Yifan Song, Elizabeth H Kellogg, James Thompson, Ian W Davis, Roland A Pache, Sergey Lyskov, Jeffrey J Gray, Tanja Kortemme, Jane S Richardson, James J Havranek, Jack Snoeyink, David Baker, Brian Kuhlman, None, Scientific Benchmarks for Guiding Macromolecular Energy Function Improvement Methods in Enzymology. ,vol. 523, pp. 109- 143 ,(2013) , 10.1016/B978-0-12-394292-0.00006-0
Ryan J. Martinez, Brian D. Evavold, Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response. Frontiers in Immunology. ,vol. 6, pp. 468- 468 ,(2015) , 10.3389/FIMMU.2015.00468