The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction.

摘要: Sepsis is a syndrome with life-threatening organ dysfunction induced by dysregulated host response to infection. The heart one of the most commonly involved organs during sepsis, and cardiac dysfunction, which usually indicative an extremely poor clinical outcome, leading cause death in septic cases. Despite substantial improvements understanding mechanisms that contribute origin responses prognosis sepsis-induced (SICD) remains its molecular pathophysiological changes are not well characterized. recently discovered group mediators known as long noncoding RNAs (lncRNAs) have presented novel insights opportunities explore development SICD may provide new targets for diagnosis therapeutic strategies. LncRNAs RNA transcripts more than 200 nucleotides limited or no protein-coding potential. Evidence has rapidly accumulated from numerous studies on how lncRNAs function associated regulatory circuits SICD. This review outlines direct evidence effect based animal trials. Furthermore, potential functional been identified sepsis summarized along proven biological research other cardiovascular diseases.