Enantioselektive Synthese von α‐Phosphinoketonen. Vorläufige Mitteilung
作者： Dieter Enders , Thorsten Berg , Gerhard Raabe , Jan Runsink
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摘要: Enantioselective Synthesis of α-Phosphinoketones The first asymmetric (CP)-connective synthesis α-phosphinoketones in high enantiomeric purity (e.e.91–97%) is described. Key step the highly diastereoselective phosphinylation SAMP-hydrazones (S)-2 to produce α-phosphinohydrazones (S,R)-3, isolated as more stable borane adducts. Subsequent ozonolysis afforded title compounds (R)-4, potential ligands for enantioselective homogeneous catalysis.
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