Selenium Cytotoxicity in Cancer

摘要: Selenium is an essential trace element with growth-modulating properties. Decades of research clearly demonstrate that selenium compounds inhibit the growth malignant cells in diverse experimental model systems. However, and cytotoxic mechanisms are far from clear. Lately, a remarkable tumour selective cytotoxicity has been shown, indicating potential treatment cancer. Of particular interest redox-active exhibiting to cells. These elicit complex patterns pharmacodynamics pharmacokinetics, leading cell death pathways differ among compounds. Modern oncology often focuses on targeted ligand-based therapeutic strategies specific their molecular targets. drugs initially efficient, but rapidly develop resistance against these drugs. In contrast, certain induce cascades pro-death signalling at pharmacological concentrations superior specificity. The target molecules ones important for survival cancer implicated drug resistance. Therefore, chemotherapeutic applications offer great possibilities multi-target attacks This MiniReview tumour-specific effects selenium, special emphasis cellular events induced by major groups pharmacologically active Furthermore, resistant cancers discussed.