Dystonia and tremor following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

摘要: Forty-seven railroad workers who were exposed to polychlorinated phenols, including dioxin (TCDD), during 1979 while cleaning up the chemical spillage following damage a tank car filled with these chemicals followed medically for subsequent 6 years. Two committed suicide. The initial neurological complaints included sense of fatigue and muscle aching, both which have been reported in other individuals exposure. On detailed examination December, 1985, 24 45 had dystonic writer's cramp and/or action dystonias hands. None involved family history dystonia, all dated onset dystonia first 2 3 years their toxic varied severity but usually mild. No types involvement recognized. Thirty-five also manifested postural terminal intention tremor resembled benign essential tremor. tremor, 35 those affected some time Forty-three patients histories findings suggestive peripheral neuropathy. This is reportmore » relating any type prior exposure report such as cramp, postural/terminal type.« less