Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

摘要: Abstract 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) was administered via the intraperitoneal route to squirrel monkeys. Akinesia, rigidity and hypophonia were seen after repeated doses of 2 mg/kg. Postural tremor present in one animal. Neuropathologic examination revealed cell loss restricted zona compacta substantia nigra. MPTP appears effective producing an animal model for Parkinson's disease squirell monkey, may be themore selective neurotoxins described date.