Photosensitivity--genetics and clinical significance.

摘要: Photosensitivity is defined by the occurrence of spikes or and waves in response to intermittent light stimulation (= photoparoxysmal [PPR]). The EEG pattern can show a wide range expression from solely occipital generalized irregular waves. different types responses represent levels same genetically determined trait. photoconvulsive Bickford et al (7) only subtype PPR characterized close relation epilepsy. average incidence 7.6% healthy children aged 1 16 years. Girls are more often affected than boys. available data provide evidence for autosomal dominant inheritance photosensitivity. Genetic heterogeneity must be considered. In studies starting neurobiological genetic point view including whole spectrum PPR, phenomenon could shown widespread condition being loosely associated with epilepsy, but symptoms psychovegetative instability. Only about 3% given definition will manifest epilepsy up age 20 According family epileptic non-epileptic photosensitive probands, phenotypical carriers' risk phenomena decisively other pathogenetic factors related Possible interactions photosensitivity within multifactorial background epilepsies reviewed.