Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer.

Stephanie Geuns-Meyer, Victor J. Cee, Holly L. Deak, Bingfan Du, Brian L. Hodous, Hanh Nho Nguyen, Philip R. Olivieri, Laurie B. Schenkel, Karina R. Vaida, Paul Andrews, Annette Bak, Xuhai Be, Pedro J. Beltran, Tammy L. Bush, Mary K. Chaves, Grace Chung, Yang Dai, Patrick Eden, Kelly Hanestad, Liyue Huang, Min-Hwa Jasmine Lin, Jin Tang, Beth Ziegler, Robert Radinsky, Richard Kendall, Vinod F. Patel, Marc Payton, Discovery of N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), a highly selective, orally bioavailable inhibitor of aurora kinases with activity against multidrug-resistant cancer cell lines. Journal of Medicinal Chemistry. ,vol. 58, pp. 5189- 5207 ,(2015) , 10.1021/ACS.JMEDCHEM.5B00183

Chiara Tuccilli, Enke Baldini, Natalie Prinzi, Stefania Morrone, Salvatore Sorrenti, Angelo Filippini, Antonio Catania, Stefania Alessandrini, Roberta Rendina, Carmela Coccaro, Massimino D’Armiento, Salvatore Ulisse, Preclinical testing of selective Aurora kinase inhibitors on a medullary thyroid carcinoma-derived cell line Endocrine. ,vol. 52, pp. 287- 295 ,(2016) , 10.1007/S12020-015-0700-0

Hielke J. Meulenbeld, Jean P. Bleuse, Elio M. Vinci, Eric Raymond, Giordano Vitali, Armando Santoro, Luigi Dogliotti, Rossana Berardi, Federico Cappuzzo, Scott T. Tagawa, Cora N. Sternberg, Maria G. Jannuzzo, Mariangela Mariani, Anna Petroccione, Ronald de Wit, Randomized phase II study of danusertib in patients with metastatic castration-resistant prostate cancer after docetaxel failure BJU International. ,vol. 111, pp. 44- 52 ,(2013) , 10.1111/J.1464-410X.2012.11404.X

Tomotoshi Marumoto, Dongwei Zhang, Hideyuki Saya, None, Aurora-A — A guardian of poles Nature Reviews Cancer. ,vol. 5, pp. 42- 50 ,(2005) , 10.1038/NRC1526

Si Li, Zhaoxuan Deng, Jingyan Fu, Caiyue Xu, Guangwei Xin, Zhige Wu, Jia Luo, Gang Wang, Shuli Zhang, Boyan Zhang, Fangdong Zou, Qing Jiang, Chuanmao Zhang, Spatial Compartmentalization Specializes the Function of Aurora A and Aurora B Journal of Biological Chemistry. ,vol. 290, pp. 17546- 17558 ,(2015) , 10.1074/JBC.M115.652453

Masaaki Tatsuka, Shiho Suto, Mikio Tanino, Fumio Suzuki, Takahide Ota, Masayo Maeda, Yasuhiko Terada, Zhen Bo Han, Hiroshi Katayama, Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability. Cancer Research. ,vol. 62, pp. 5168- 5177 ,(2002)

Daniel Benten, Gunhild Keller, Alexander Quaas, Jorg Schrader, Artur Gontarewicz, Stefan Balabanov, Melanie Braig, Henning Wege, Jurgen Moll, Ansgar W. Lohse, Tim H. Brummendorf, Aurora Kinase Inhibitor PHA-739358 Suppresses Growth of Hepatocellular Carcinoma In Vitro and in a Xenograft Mouse Model Neoplasia. ,vol. 11, pp. 934- 944 ,(2009) , 10.1593/NEO.09664

Hem C. Jha, Karren Yang, Darine W. El-Naccache, Zhiguo Sun, Erle S. Robertson, EBNA3C regulates p53 through induction of Aurora kinase B. Oncotarget. ,vol. 6, pp. 5788- 5803 ,(2015) , 10.18632/ONCOTARGET.3310

Dominik Bogen, Jun S. Wei, David O. Azorsa, Pinar Ormanoglu, Eugen Buehler, Rajarshi Guha, Jonathan M. Keller, Lesley A. Mathews Griner, Marc Ferrer, Young K. Song, Hongling Liao, Arnulfo Mendoza, Berkley E. Gryder, Sivasish Sindri, Jianbin He, Xinyu Wen, Shile Zhang, John F. Shern, Marielle E. Yohe, Sabine Taschner-Mandl, Jason M. Shohet, Craig J. Thomas, Scott E. Martin, Peter F. Ambros, Javed Khan, Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma Oncotarget. ,vol. 6, pp. 35247- 35262 ,(2015) , 10.18632/ONCOTARGET.6208

Erich A. Nigg, Mitotic kinases as regulators of cell division and its checkpoints Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 21- 32 ,(2001) , 10.1038/35048096