CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes.
作者： Akihiko Kuniyasu , Nobutaka Ohgami , Shigeki Hayashi , Akira Miyazaki , Seikoh Horiuchi
DOI: 10.1016/S0014-5793(03)00096-6
关键词:
摘要: Interaction of advanced glycation end products (AGE) with AGE receptors induces several cellular phenomena potentially relating to diabetic complications. We here show that AGE-modified bovine serum albumin (BSA) is endocytosed by adipocytes via CD36. Upon differentiation, 3T3-L1 and human subcutaneous adipose cells showed marked increases in endocytic uptake subsequent degradation [125I]AGE-BSA, which were inhibited effectively the anti-CD36 antibody. Ligand specificity CD36 for modified BSAs was compared LOX-1 scavenger receptor class A. Effect fucoidan on [125I]AGE-BSA binding a sharp contrast [125I]-oxidized low density lipoprotein. These results implicate CD36-mediated interaction proteins might play pathological role obesity or insulin-resistance.
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