NF2 status of meningiomas is associated with tumour localization and histology

作者: Johan Kros , Kitty de Greve , Angela van Tilborg , Wim Hop , Herman Pieterman

DOI: 10.1002/PATH.909

关键词:

摘要: In approximately 60% of sporadic meningiomas, the tumour suppressor gene NF2, located on chromosome 22q, is inactivated. Mutations in NF2 have been specifically reported transitional and fibrous, but not meningothelial, meningiomas. Since meningothelial meningiomas frequently occur anterior parts skull base, association between localization, size, histological subtype status was investigated a group 42 determined by LOH analysis, karyotyping FISH. Tumour size site were evaluated CT scans MRIs. A strong correlation localization base intact 22q revealed (p=0.003). On other hand, at convexity associated with disruption (p=0.023). Furthermore, an 22 observed: abnormalities more frequent fibrous than variant (p<0.001). Also, often (p<0.006). Based these findings, it concluded that alternative histogenesis genetic pathway likely to exist for arising base. Copyright © 2001 John Wiley & Sons, Ltd.

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