Sar1-Ala8 angiotensin II blocks renin-angiotensin but not beta-adrenergic dipsogenesis
作者： Maisy Tang , John L. Falk
DOI: 10.1016/0091-3057(74)90087-2
关键词:
摘要: Abstract Continuous, intravenous (IV) infusion (10 μg/min) of Sar1-Ala8 angiotensin II (P-113), an blocking analog, into rats greatly attenuated water intake resulting from IV renin (4 U) and (80 μg). P-113 did not attenuate the drinking induced by subcutaneous (SC) administration beta-adrenergic agents: isoproterenol (0.05 mg/kg), quinterenol diazoxide (40 mg/kg). also functioned as a weak agonist with respect to response. It was concluded that dipsogenesis in attributable release but does depend upon some unknown renal endocrine factor.
elsevier.com
sci-hub.se 参考文章(45)
B. Peskar, S. Leodolter, G. Hertting, Die Wirkung verschiedener blutdrucksenkender Pharmaka auf Wasseraufnahme und -abgabe bei Ratten Naunyn-Schmiedebergs Archiv f�r Pharmakologie. ,vol. 265, pp. 1823- 1834 ,(1970) , 10.1007/BF00997191
A. N. Epstein, S. Hsiao, Angiotensin as Dipsogen Springer, Berlin, Heidelberg. pp. 108- 116 ,(1975) , 10.1007/978-3-642-61907-6_18
Miguel A. Ondetti, Nina J. Williams, Emily Sabo, Josip Pluscec, Eugene R. Weaver, Octavian Kocy, Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca. Isolation, elucidation of structure, and synthesis. Biochemistry. ,vol. 10, pp. 4033- 4039 ,(1971) , 10.1021/BI00798A004
D. Lehr, H. W. Goldman, P. Casner, Renin-Angiotensin Role in Thirst: Paradoxical Enhancement of Drinking by Angiotensin Converting Enzyme Inhibitor Science. ,vol. 182, pp. 1031- 1034 ,(1973) , 10.1126/SCIENCE.182.4116.1031
David Lehr, Warren Goldman, Continued pharmacologic analysis of consummatory behavior in the albino rat European Journal of Pharmacology. ,vol. 23, pp. 197- 210 ,(1973) , 10.1016/0014-2999(73)90057-5
D. K. Meyer, W. Rauscher, B. Peskar, G. Hertting, The mechanism of the drinking response to some hypotensive drugs: activation of the renin-angiotensin system by direct or reflex-mediated stimulation of -receptors. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 276, pp. 13- 24 ,(1973) , 10.1007/BF00500774
H.S. Cheung, D.W. Cushman, Inhibition of homogeneous angiotensin-converting enzyme of rabbit lung by synthetic venom peptides of Bothrops jararaca. Biochimica et Biophysica Acta. ,vol. 293, pp. 451- 463 ,(1973) , 10.1016/0005-2744(73)90352-5
L.W. Swanson, G.R. Marshall, P. Needleman, L.G. Sharpe, Characterization of central angiotensin II receptors involved in the elicitation of drinking in the rat. Brain Research. ,vol. 49, pp. 441- 446 ,(1973) , 10.1016/0006-8993(73)90438-1
D. K. Meyer, G. Hertting, Influence of neuronal uptake-blocking agents on the increase in water intake and in plasma concentrations of renin and angiotensin I induced by phentolamine and isoprenaline Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 280, pp. 191- 200 ,(1973) , 10.1007/BF00499180
Katherine A. Houpt, Alan N. Epstein, The complete dependence of beta-adrenergic drinking on the renal dipsogen Physiology & Behavior. ,vol. 7, pp. 897- 902 ,(1971) , 10.1016/0031-9384(71)90061-8