Effect of Antipsychotic Medication Alone vs Combined With Psychosocial Intervention on Outcomes of Early-Stage Schizophrenia: A Randomized, 1-Year Study

摘要: Context Antipsychotic drugs are limited in their ability to improve the overall outcome of schizophrenia. Adding psychosocial treatment may produce greater improvement functional than does medication alone. Objective To evaluate effectiveness antipsychotic alone vs combined with intervention on outcomes early-stage Design Randomized controlled trial. Setting Ten clinical sites China. Participants Clinical sample 1268 patients schizophrenia treated from January 1, 2005, through October 31, 2007. Intervention Patients were randomly assigned receive only or plus 12 months consisting psychoeducation, family intervention, skills training, and cognitive behavior therapy administered during 48 group sessions. Main Outcome Measures The rate discontinuation change due any cause, relapse remission, assessments insight, adherence, quality life, social functioning. Results rates cause 32.8% 46.8% medication-alone group. Comparisons showed lower risk any-cause (hazard ratio, 0.62; 95% confidence interval, 0.52-0.74; P  = .002), activities daily living (  ≤ .02). Furthermore, a significantly higher proportion receiving obtained employment accessed education  = .001). Conclusion Compared those only, have change, relapse, improved Trial Registration clinicaltrials.gov Identifier:NCT00654576