A New Technique to Efficiently Entrap Leuprolide Acetate into Microcapsules of Polylactic Acid or Copoly(Lactic/Glycolic) Acid

摘要: The aim of this work was to develop injectable microcapsules containing leuprolide acetate, that would deliver drug at a zero-order rate over period about one month. A large amount hydrophilic drug, entrapped into polylactic aicd (PLA) and copoly-(lactic/glycolic) acid (PLGA) prepared by an in-water dring method using (w/o)/w emulsion. basic techniques were designed increase the viwcosities inner water phase w/o Under conditions used, it possible for be completely in range 10 20% on basis polymer. However, release profiles vitro inadequate controlled