Self-reguiating isnssultn delivery systems II. In vitro studies

摘要: Abstract A design for a self-regulating insulin delivery system based on the competitive binding of glucose and glycosylated to lectin Concanavalin is proposed. different approach diabetes therapy attempt effect permanent cure disease by supplementing patient's defective pancreas with normally functioning transplant. However, pancreatic transplantation in humans stilt its early stage, major problems including rejection transplants still remain unsolved. In phase one this investigation, described companion paper, eight derivatives were synthesized. experiments here it was found that insulins all show biological activity; several are also more stable against aggregation than commercial insulin. Of various hydrogel membranes studied, porous poly (hydroxyethyl methacrylate) showed optimum diffusvity ; p- HEMA therefore selected as being most suitable further investigation. The exchange release two , (succinylamido)phenyl-α-D-mannopyranoside—insulin (succinylamido)phenyl-α-D-glucopyranoside—insulin, through shows considerable promise use .