Protein–protein interactions of ASPP2: an emerging therapeutic target
作者： Anat Iosub-Amir , Assaf Friedler
DOI: 10.1039/C4MD00147H
关键词:
摘要: The pro-apoptotic ASPP2 protein plays a central role in regulating apoptosis both p53-dependent and p53-independent pathways. It has become clear recent years that also other important cellular processes like senescence cell polarity. interacts with numerous proteins order to exert its effect while some inhibit activity. These interactions are emerging potential targets for activation or inhibition. Drugs activate may not only induce of cancer cells, but affect disease-related Here we review the partner their targeting drug development.
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