The development of delusion revisited: a transdiagnostic framework.

摘要: Abstract This study proposes a transdiagnostic framework for delusion development, analysing psychiatric (schizophrenia, bipolar disorder, major depressive disorder) and neurological disorders (stroke, neurodegenerative diseases) in which delusions are predominant. Our aim is to identify core of neural cognitive alterations associated with across distinct clinical disorders. Reviewed empirical evidence suggests associated: on the level changes ventromedial prefrontal cortex (vmPFC) networks, neuropsychological dysfunction processes (generation affective value, construction internal models world, reflection about Self and/or Other′s mental states) that these network mediate. The concurrent aberration all could be critical transition psychotic delusional state. In particular, become clinically manifest when (1) stimuli attributed an aberrant salience, (2) explained by patient within distorted explanatory (3) poorly inhibited control systems. extends two-factor account model common mechanisms