Giant lamellar bodies as a feature of pulmonary low-grade MALT lymphomas.

摘要: Aims Giant lamellar bodies (GLBs) are rare pulmonary inclusions, most frequently described in sclerosing haemangiomas. Following a recent report of their presence case lymphoma MALT origin, our aims were to determine frequency lymphoproliferative disorders, examine structure and investigate aetiology further. Methods results We reviewed series 29 lymphomas (23 low-grade, six high-grade) 18 cases reactive lymphoid hyperplasia. Five 23 (22%) low-grade contained GLBs, 4/4 which stained for surfactant apoprotein A but not B. No GLBs seen hyperplasia or high-grade primary lymphomas. Ultrastructural examination revealed concentrically arranged extracellular material forming roughly spherical structures up 25 μm diameter. The often surrounded by foamy cells cholesterol clefts, supporting an at least part, from products cell breakdown degradation. Conclusion These findings support the idea that is part due stasis arising degradation surfactant, association with certain types chronic pathology. Given absence hyperplasia, as epiphenomenon infiltrate should warrant careful investigation regard diagnosis lymphoma.