Title: Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins 1 following BCG vaccination 2 3

作者： Hazel M. Dockrell , Kris Huygen , Steven G. Smith , H Annemieke , Annemieke Geluk

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摘要: Abstract 2 BCG is widely used as a vaccine against tuberculosis (TB) despite its variable protective 3 efficacy. Relatively little known about the immune response profiles following 4 vaccination in relation to protection TB. Here we tested whether 5 results responses DosR (Rv3133c) regulon encoded proteins. These so-called 6 TB latency antigens are targeted by system during persistent Mycobacterium 7 infection and have been associated with immunity latent M. 8 infection. 9 In silico analysis of showed at least 97% 10 homology amino acid sequence, 41 out 48 genes being identical. Transcriptional 11 profiling 14 different strains, under hypoxia nitric oxide exposure vitro, 12 revealed functional similar that observed . 13 Next, assessed human series immuno-dominant found

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Title: Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins 1 following BCG vaccination 2 3

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Title: Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins 1 following BCG vaccination 2 3

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