Cell Death from Antibiotics Without the Involvement of Reactive Oxygen Species

作者: Y. Liu , J. A. Imlay

DOI: 10.1126/SCIENCE.1232751

关键词:

摘要: Recent observations have suggested that classic antibiotics kill bacteria by stimulating the formation of reactive oxygen species (ROS). If true, this notion might guide new strategies to …

参考文章(35)
Anh N. Woodmansee, James A. Imlay, Quantitation of intracellular free iron by electron paramagnetic resonance spectroscopy. Methods in Enzymology. ,vol. 349, pp. 3- 9 ,(2002) , 10.1016/S0076-6879(02)49316-0
C.F. Kuo, T. Mashino, I. Fridovich, alpha, beta-Dihydroxyisovalerate dehydratase. A superoxide-sensitive enzyme. Journal of Biological Chemistry. ,vol. 262, pp. 4724- 4727 ,(1987) , 10.1016/S0021-9258(18)61255-4
Masami Yamada, Masatomi Shimizu, Atsushi Katafuchi, Petr Grúz, Shingo Fujii, Yukio Usui, Robert P. Fuchs, Takehiko Nohmi, E scherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains Molecular Microbiology. ,vol. 86, pp. 1364- 1375 ,(2012) , 10.1111/MMI.12061
J A Imlay, I Fridovich, Assay of metabolic superoxide production in Escherichia coli Journal of Biological Chemistry. ,vol. 266, pp. 6957- 6965 ,(1991) , 10.1016/S0021-9258(20)89596-9
P R Gardner, I Fridovich, Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase. Journal of Biological Chemistry. ,vol. 266, pp. 1478- 1483 ,(1991) , 10.1016/S0021-9258(18)52319-X
H W Taber, J P Mueller, P F Miller, A S Arrow, Bacterial uptake of aminoglycoside antibiotics. Microbiological Research. ,vol. 51, pp. 439- 457 ,(1987) , 10.1128/MR.51.4.439-457.1987
Stefan I. Liochev, Irwin Fridovich, The role of O2.− in the production of HO.: in vitro and in vivo Free Radical Biology and Medicine. ,vol. 16, pp. 29- 33 ,(1994) , 10.1016/0891-5849(94)90239-9
Ken-ichi Setsukinai, Yasuteru Urano, Katsuko Kakinuma, Hideyuki J. Majima, Tetsuo Nagano, Development of Novel Fluorescence Probes That Can Reliably Detect Reactive Oxygen Species and Distinguish Specific Species Journal of Biological Chemistry. ,vol. 278, pp. 3170- 3175 ,(2003) , 10.1074/JBC.M209264200
K. Keyer, J. A. Imlay, Superoxide accelerates DNA damage by elevating free-iron levels Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 13635- 13640 ,(1996) , 10.1073/PNAS.93.24.13635