Factors associated with active tuberculosis in Colombian patients with systemic lupus erythematosus: a case-control study

摘要: To identify factors associated with active tuberculosis (TB) in patients systemic lupus erythematosus (SLE). We performed a retrospective case-control study two tertiary care teaching hospitals Medellin, Colombia. From January 2007 to December 2017, total of 268 SLE were included. TB (cases) matched 1:3 without (controls) by disease duration and the date hospitalization which diagnosis was made (index cases) nearest available rheumatology controls (± 2 years). Conditional univariable multivariable logistic regression analyses performed. Sixty-seven cases 201 assessed. Only pulmonary occurred 46.3%, only extrapulmonary 16.4% disseminated 37.3% cases. Multivariable analysis showed that lymphopenia (OR, 2.91; 95% CI 1.41–6.03; P = 0.004), 12-month cumulative glucocorticoid dose ≥ 1830 mg 2.74; 1.26–5.98; P = 0.011), having been treated ≥ 2 immunosuppressants during last 12 months 2.81; 1.16–6.82; P = 0.022) after adjusting for age, sex, ethnicity, duration, activity, comorbidity index. A trend towards an association kidney transplantation also found 3.77; 0.99–14.30; P = 0.051). Among patients, dose, lymphopenia, use infection.