Role of vitamin K-dependent proteins in the arterial vessel wall

摘要: Vitamin K was discovered early last century at the same time as vitamin K-antagonists. For many years role of solely ascribed to coagulation and thought be involved only venous blood side. This view has dramatically changed with discovery K-dependent proteins outside cascade factors arterial are in regulation vascular smooth muscle cell migration, apoptosis, calcification. Vascular calcification become an important independent predictor cardiovascular disease. K-antagonists induce inactivity inhibitors calcification, leading accelerated The involvement such MGP make that is amendable for intervention high intake K. review focuses on effect