Regulation of Plasma High Density Lipoprotein Concentration by Lipoprotein Lipase and Hepatic Endothelial Lipase

摘要: A number of epidemiologic and angiographic studies have established that the risk developing ischemic heart disease (IHD) extent coronary atherosclerosis bear a direct relationship to plasma LDL cholesterol concentration but are inversely correlated HDL cholesterol.1,2 The latter association seems be mostly mediated by HDL2 subfraction.3 question on possible additional role elevated triglyceride VLDL levels in increasing IHD has remained controversial.4 Many authors agree hypertriglyceridemia is common among patients with alsopredicts new IHD5, 6 multivariate analyses considering also consistently eliminated triglycerides as an independent factor.4 In other words, indicates increased only because its close inverse HDL. Thus, high not atherogenic if accompanied low It evident significance protective factor increases concentration. Accordingly, populations (usually due diet) simultaneous atherogenic.