Breast relapse following primary radiation therapy for early breast cancer. II. Detection, pathologic features and prognostic significance.

摘要: Abstract In order to define better the nature of breast relapse following primary radiation therapy for early-stage invasive cancer, we examined clinical patterns, methods detection, histopathology and prognosis in 25 patients. Eighty-eight percent these relapses occurred vicinity original tumor at an average 33 months after treatment. Twelve a location distinctly separate from area 75 14 patients was detected by physical examination (PE) alone, 6 mammography alone 5 both. eight whose were PE not performed; mammograms negative other six. 89% who presented with new abnormality on examination, recurrence consisted predominantly or exclusively carcinoma. contrast, all six only abnormality, intraductal Eighteen underwent salvage mastectomy, 3 inoperable grounds 4 refused mastectomy. Only 1 18 mastectomy had significant complication related surgery. Twenty-one (84%) are alive without further up 67 (mean 24 months) relapse. We conclude that (1) both important detection relapses: (2) secondary (salvage) surgery can be performed complications; (3) does have same grave as local (chest wall)