Csr (Rsm) System and Its Overlap and Interplay with Cyclic Di-GMP Regulatory Systems

摘要: Free-living bacteria must respond rapidly to changing environmental and physiological conditions survive stresses, maintain homeostasis growth, compete with other species. This chapter describes recent evidence of shared regulatory targets interconnections between two global systems that antagonistically influence bacterial lifestyle choices by governing surface properties, biofilm development, motility, in many species, virulence factors. The CsrD protein, which triggers the turnover CsrB CsrC RNAs RNaseE, contains degenerate GGDEF EAL domains but does not synthesize or degrade cyclic di-GMP (c-di-GMP). illustrates interactions Csr its interplay c-di-GMP systems. Various features (Rsm) system have been subjects previous reviews. BarA-UvrY homologs, are present gram-negative bacteria, variously known as Gac, Var, Exp, Let two-component signal transduction (TCS), also work conjunction Importantly, activates rpoS transcription E. coli, possibly through DNA binding response regulator UvrY. Synthesis from GTPs is catalyzed diguanylate cyclases (DGC) contain (DUF-1) domain. A recently discovered element a protein riboswitch. RNA domain aptamer was originally identified conserved GEMM sequence motif (genes for environment, membranes, motility) 5'-untranslated segment numerous mRNAs involved metabolism, virulence, pilus formation.