Trends of mutation accumulation across global SARS-CoV-2 genomes: Implications for the evolution of the novel coronavirus

作者: Ranadhir Chakraborty , Chayan Roy , Santi M. Mandal , Suresh K. Mondal , Shriparna Mukherjee

DOI: 10.1016/J.YGENO.2020.11.003

关键词:

摘要: To understand SARS-CoV-2 microevolution, this study explored the genome-wide frequency, gene-wise distribution, and molecular nature of all point-mutations detected across its 71,703 RNA-genomes deposited in GISAID till 21 August 2020. Globally, nsp1/nsp2 orf7a/orf3a were most mutation-ridden non-structural structural genes respectively. Phylogeny 4618 spatiotemporally-representative genomes revealed that entities belonging to early lineages are mostly spread over Asian countries, including India, whereas recently-derived more globally distributed. Of total 20,163 instances polymorphism global genomes, 12,594 7569 involved transitions transversions, predominated by cytidine-to-uridine guanosine-to-uridine conversions, Positive selection nonsynonymous mutations (dN/dS >1) structural, but not non-structural, indicated has already harmonized replication/transcription machineries with host metabolism, while it is still redefining virulence/transmissibility strategies at level. Mechanistic bases evolutionary/pathogenicity-related implications discussed for predominant mutation-types.

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