Gender, body mass index and rheumatoid arthritis disease activity: results from the QUEST-RA Study.

摘要: OBJECTIVES: To investigate whether body mass index (BMI), as a proxy for fat, influences rheumatoid arthritis (RA) disease activity in gender-specific manner. METHODS: Consecutive patients with RA were enrolled from 25 countries into the QUEST-RA program between 2005 and 2008. Clinical demographic data collected by treating rheumatologists patient self-report. Distributions of Disease Activity Scores (DAS28), BMI, age, duration assessed each country entire dataset; mean values genders compared using Student's t-tests. An association BMI DAS28 was investigated linear regression, adjusting country. RESULTS: A total 5,161 (4,082 women 1,079 men) included analyses. Overall, younger, had longer duration, higher scores than men, but similar genders. The increased increasing normal to overweight obese, among women, whereas opposite trend observed men. Regression results showed (continuous or categorical) be associated DAS28. Compared range, being obese larger difference (0.23, 95% CI: 0.11, 0.34) (0.12, 0.03, 0.21); underweight not activity. These associations more pronounced explained any single component CONCLUSIONS: appears