Molecular Pathology: Applications in Nonclinical Drug Development
作者： L. Oyejide , O.R. Mendes , I. Mikaelian
DOI: 10.1016/B978-0-12-803620-4.00016-5
关键词:
摘要: Abstract In this chapter, the preclinical applications of several molecular pathology technologies in advancing drug discovery and development are discussed, including immunohistochemistry, immunofluorescence, situ hybridization RNAScope, tissue microarrays, laser-capture microscopy, toxicogenomics, biomarkers, digital imaging, stereology, microRNA analysis. Examples provided to illustrate utility each specific technology for identification, characterization, elucidation pathogenetic mechanism(s) drug-related alterations.
sci-hub.se 参考文章(278)
Cristian T. Badea, Elizabeth Bucholz, Laurence W. Hedlund, Howard A. Rockman, G. Allan Johnson, Imaging methods for morphological and functional phenotyping of the rodent heart. Toxicologic Pathology. ,vol. 34, pp. 111- 117 ,(2006) , 10.1080/01926230500404126
J. A. Ramos-Vara, Technical aspects of immunohistochemistry. Veterinary Pathology. ,vol. 42, pp. 405- 426 ,(2005) , 10.1354/VP.42-4-405
B P Hierck, L V Iperen, A C Gittenberger-De Groot, R E Poelmann, Modified indirect immunodetection allows study of murine tissue with mouse monoclonal antibodies. Journal of Histochemistry and Cytochemistry. ,vol. 42, pp. 1499- 1502 ,(1994) , 10.1177/42.11.7930532
David P. Bartel, MicroRNAs: Target Recognition and Regulatory Functions Cell. ,vol. 136, pp. 215- 233 ,(2009) , 10.1016/J.CELL.2009.01.002
Sandra E Juul, Ryan M McAdams, Ronald J McPherson, Nazila M Dabestani, Christine A Gleason, Left ventricular hypertrophy is prevalent in Sprague-Dawley rats Comparative Medicine. ,vol. 60, pp. 357- 363 ,(2010)
Awal M. Hadi, Koen T. B. Mouchaers, Ingrid Schalij, Katrien Grunberg, Gerrit A. Meijer, Anton Vonk-Noordegraaf, Willem J. van der Laarse, Jeroen A. M. Beliën, Rapid quantification of myocardial fibrosis: a new macro-based automated analysis Cellular Oncology. ,vol. 33, pp. 257- 269 ,(2010) , 10.1007/S13402-011-0035-7
James A. Swenberg, Daniel R. Dietrich, The Presence of α2u-Globulin Is Necessary for d-Limonene Promotion of Male Rat Kidney Tumors Cancer Research. ,vol. 51, pp. 3512- 3521 ,(1991)
B A Ponder, M M Wilkinson, Inhibition of endogenous tissue alkaline phosphatase with the use of alkaline phosphatase conjugates in immunohistochemistry. Journal of Histochemistry & Cytochemistry. ,vol. 29, pp. 981- 984 ,(1981) , 10.1177/29.8.7024402
Carmen J. Allegra, J. Milburn Jessup, Mark R. Somerfield, Stanley R. Hamilton, Elizabeth H. Hammond, Daniel F. Hayes, Pamela K. McAllister, Roscoe F. Morton, Richard L. Schilsky, American Society of Clinical Oncology Provisional Clinical Opinion: Testing for KRAS Gene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti-Epidermal Growth Factor Receptor Monoclonal Antibody Therapy Journal of Clinical Oncology. ,vol. 27, pp. 2091- 2096 ,(2009) , 10.1200/JCO.2009.21.9170
Douglas M. Minot, Benjamin R. Kipp, Renee M. Root, Reid G. Meyer, Carol A. Reynolds, Aziza Nassar, Michael R. Henry, Amy C. Clayton, Automated cellular imaging system III for assessing HER2 status in breast cancer specimens: development of a standardized scoring method that correlates with FISH. American Journal of Clinical Pathology. ,vol. 132, pp. 133- 138 ,(2009) , 10.1309/AJCPJV0SKAF2PCMY