Age-related early/late variations of functional connectivity across the human lifespan.

摘要: Many questions remain regarding how the brain develops, matures, and ages across lifespan. The functional connectivity networks in resting-state can reflect many of characteristic changes that are associated with increasing age. Functional has been shown to be time-dependent over course a lifespan even minutes. strategies all cognitive dynamic is age unclear. In this paper, studies employing both linear quadratic models define new specific strategies, including early/late increase/decrease models, were conducted explore changes. A large data sample was retrieved from publicly available Nathan Kline Institute (N = 149 9–85). Both static indexes calculated connectivity, mean variations connectivity. between-network results revealed early increases default-mode (DF) cingulo-opercular network (CO)-associated connectivities late increase fronto-parietal (FP)-associated These depicted various for different development stages Additionally, FC exhibited consistent results, their variation constant decrease entire range. (FDR-corrected p value < 0.05) suggest could an association between varied complex circumstances development.