Asymmetric aminocatalysis: a modern strategy for molecules, challenges and life

摘要: The studies conducted during my Phd thesis were focused on two different directions: 1. In one case we tried to face some long standing problems of the asymmetric aminocatalysis as activation encumbered carbonyl compounds and control diastereoisomeric ratio in diastero- enantioselective construction all carbon substituted quaternary stereocenters adjacent a tertiary one. this section (Challenges) was described aziridination ,-unsaturated ketones, -branched aldehydes Michael addition oxindoles enals enones. For via iminium ion formation sterically demanding substrates, ketones aldehydes, exploited chiral primary amine order overcome problem between catalyst carbonylic componds. For envisaged that suitable strategy 3 activated LUMO-lowering catalysis. In synthetic protocol designed new bifunctional with an moiety for activate aldehyde tioureidic fragment direct approach oxindole. This part could be considered pure basic research, where solution goal itself research. 2. other hand (Molecules) applied our knowledge about cascade reaction synthesis three classes spirooxindole enantiopure form. The libraries these bioactive represented scientific bridge medicinal chemistry or biology catalysis.