Analysis of Immune Cell Repopulation After Anti-thymocyte Globulin Administration for Steroid-Resistant T-cell-mediated Rejection.

摘要: Abstract Background Anti-thymocyte globulin (ATG) is a treatment option for steroid-resistant T-cell–mediated rejection after kidney transplantation. However, the extent to which immune-cell subsets can repopulate peripheral blood unknown. Methods Six patients with were recruited and underwent analysis of their immune cells 1 year ATG administration. Multicolor flow cytometric was used evaluate proportions T cells, B natural killer monocytes. Results T-cell repopulation from 24% 75% occurred in group. The major repopulated effector memory CD8+ followed by CD4+ cells. population low expression interleukin-7 receptor α increased over time. regulatory (eg, CD8+CD28-CD56+ CD4+CD25bright cells) populations other subsets, including monocytes, not significantly altered ATG. Conclusions Our findings on cell administration will enable future studies aiming unravel steroid-resistance mechanism underlying rejection.