Acquired resistance to acyclovir: laboratory phenomenon or clinical problem?

摘要: Summary In tissue culture, herpes simplex readily acquires resistance to nucleoside analogue inhibitors such as acyclovir. The two possible sites where may develop are in the thymidine kinase (TK) and DNA polymerase genes; commonest vitro mutant is TK negative (TK − ), although some strains induce low levels of enzyme activity. characteristics modes selection these mutants discussed, together with a preliminary consideration situation man when antiviral drugs come be more widely used.