Advances in the discovery and development of trematocidal drugs

摘要: More than 10% of the world's population are at risk schistosomiasis and food-borne trematodiasis an estimated 250 million individuals infected with causative agents, namely trematode worms. Yet, so-called neglected tropical diseases because they affect poorest people world. There only two drugs available for treatment control trematodiasis, praziquantel triclabendazole. Discovered in 1970s 1980s, these show a good safety profile, efficacious after administration single oral doses have become inexpensive. Because global poor, there is little incentive Western pharmaceutical manufacturers to invest development new trematocidal drugs. Fortunately, we witnessing sea change disease drug landscape that should facilitate discovery, deployment...