Synthesis of substance P analogs and agonistic and antagonistic activities.

摘要: Fourteen analogs of substances P (SP), six previously synthesized by a solution method and eight newly solid-phase technique, have been tested for agonistic antagonistic activities utilizing the isolated guinea pig ileum. The primary objective is to achieve effective inhibitors SP. These had ranging from negligible that equivalent Six fourteen some degree activity [D-Leu8, D-Phe9]-SP an analog which constitutes lead new substitutions, because it activity, but only activity. One concept requires or no