The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: I. Background, experimental strategy and critique
作者： Joe L. Mauderly
DOI: 10.3109/08958378.2014.923546
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摘要: AbstractThe National Environmental Respiratory Center Program was initiated as an experiment to explore strategies for identifying the components of complex air pollution mixtures that cause health effects associated statistically with pollution. A strategy involving multivariate analysis a composition-concentration-response database adopted. novel created by exposing rodents daily up six months one four combustion-related and measuring respiratory, cardiovascular general toxicological responses after week or exposure. The included multiple concentrations diesel gasoline engine exhaust, hardwood smoke simulated downwind coal combustion emissions. After reporting biological each mixture comparing among them, 47 significant were selected additive regression tree identify putative causal components. Although provided marginally suff...
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